The comparison between Platelet-Rich Plasma (PRP) therapy and autologous serum eye drops for the treatment of dry eye syndrome is complex and multifaceted, with both therapies offering unique benefits and considerations. 

Studies show PRP is a stronger, more efficacious agent for delivering higher concentrations of platelets, which are rich in growth factors, cytokines, and other bioactive molecules known to strongly promote tissue regeneration, wound healing, and angiogenesis. These factors stimulate epithelial proliferation, reduce inflammation, and improve tear film stability, making PRP an excellent option for treating tough to treat dry eye syndrome especially useful for alleviating ocular pain and neurotrophic keratitis (loss of corneal nerves that help to keep the ocular surface healthy) .

Autologous Serum: Autologous serum  are also eye drops that contain a natural but lower concentration  of growth factors, vitamins, and proteins essential for ocular surface health. While less concentrated than PRP, autologous serum still provides nourishment and support to the ocular surface, promoting epithelial healing, reducing inflammation, and improving symptoms associated with dry eye.

Clinical Evidence: 

PRP: Research on PRP for dryA study published in the 'American Journal of Ophthalmology' reported significant improvements in dry eye symptoms, tear film stability, and corneal epithelial healing following PRP treatment. However, larger randomized controlled trials are needed to further evaluate its efficacy and long-term outcomes.

Autologous Serum: Autologous serum eye drops have been extensively studied and demonstrated efficacy in improving symptoms and signs of dry eye syndrome. Multiple clinical trials and meta-analyses have reported reductions in ocular surface inflammation, corneal staining, and subjective discomfort with autologous serum therapy. 


PRP: PRP therapy requires specialized equipment for blood processing and centrifugation, as well as trained healthcare professionals to administer the treatment. The procedure may also be associated with higher costs compared to autologous serum eye drops.

Autologous Serum: Autologous serum eye drops are relatively easy to prepare and can be compounded in a pharmacy using standard protocols or with a simple in-office centrifuge which does not capture the most potent parts of a patient’s own regenerative capabilities.. 

While both therapies harness the body’s own abilities to heal itself by concentrating the growth factors and cytokines that lead to healing, PRP is the clear winner in terms of potency, power and the ability to address the toughest ocular surface conditions. Autologous serum can be useful for less severe dry eye cases and as maintenance after received a round or two of PRP. If you would like to explore the benefits of PRP and autologous serum for the treatment of your drye eye, call 615.327.4015 or head to to learn more and schedule your personalized telehealth consultation. Help your body heal itself naturally with PRP from the Toyos Clinic.