Intense Pulse Light: For Treating Dry Eye - Review of Ophthalmology 2010 - Christopher Kent, Senior Editor

One key source of potential tear-film trouble is the meibomian glands. If the glands malfunction, the lipid layer may be reduced, allowing rapid evaporation of the tear complex. Furthermore, if the glands' secretions become trapped inside the glands, inflammation and bacteria can follow, worsening the problem.

For the past eight years, Rolando Toyos, MD, medical director and founder of Toyos Clinic in Memphis, has been refining a new approach to treating this problem, using intense pulsed light, or IPL, originally developed for use in dermatology. Brief, powerful bursts of light at specific wavelengths (in this case, between 500 and 800 nm) cause changes in blood vessels near the surface of the skin, raise skin temperature and eliminate problematic flora on the skin and eyes,1-5 all of which may have a beneficial effect on meibomian gland dysfunction.

Making The Discovery:

Dr. Toyos says he discovered this potential use of intense pulsed light by accident after opening an aesthetics clinic in his practice in 2002. "IPL is FDA-approved for patients with rosacea and acne," he explains. "The light that's emitted from the flashlamp is absorbed by the oxyhemoglobin in the blood vessels on the skin's surface; the absorption generates heat that coagulates the cells, leading to thrombosis of the blood vessels.1-4 This minimizes redness and improves the look of the skin. IPL is FDA-approved for patients with rosacea and acne. My rosacea patients who had the IPL treatment would return with their skin looking much better—but some also mentioned that their eyes felt better. On examination, their eyes really were better, even though the IPL treatment wasn't done directly on the glands.

"So, we began investigating this using different IPL instruments, none of which were designed to treat meibomian gland dysfunction," he says. "We got mixed results. Then in 2003 we received an ASCRS grant to pursue this, and we conducted a small study in which patients with MGD were treated with IPL on one side and nothing on the other side. We found that during some of the time points following treatment, their MGD was better; the lids looked clearer, there was less erythema, fewer blood vessels, thinner secretions, and most important, reduced symptoms."

However, the existing technology was inconsistent, and the bulb's intensity would diminish over time. Dr. Toyos worked with one of the companies, Dermamed, to solvethese problems. "Now, we have an instrument that's safe, with reproducible results," he says. (Dr. Toyos emphasizes that doctors should not attempt this using just any IPL equipment.)

Dr. Toyos says one immediate effect of IPL is that it acts like the "world's best warm compress."IPL acts like the world's best warm compress. "When the light is absorbed by the blood vessels, it generates heat in the dermal layer that melts the secretions and opens the glands," he explains. "So, immediately after treatment we express the glands. We can get out all of the secretions that were stagnating, so patients get some relief right away."

Research in the field of dermatology has uncovered several other relevant effects of IPL treatment. "For one thing, by closing off the blood vessels near the surface of the skin it decreases the inflammatory cytokines6 that contribute to meibomian gland dysfunction," he says. "In addition, IPL decreases the bacterial load on the skin, which is one of the reasons it helps with acne. There's also some evidence that IPL decreases parasites on the eyelash margin that can cause meibomian gland problems."

Performing the Procedure:

"When the patient comes in, we determine the skin type and how severe the meibomian gland dysfunction is," Dr. Toyos explains. "This treatment should only be used for patients whose skin is Fitzpatrick type four or below, to avoid causing lightening of the skin color. We then give the treatment from ear to ear; if we just treat the lid, the blood vessels grow back much sooner, requiring more maintenance treatments. Next, after putting an eye shield over the eyes we treat the lower lid."

Dr. Toyos notes that he doesn't directly treat the upper glands. "First of all, when you hit the side of the lid, you close off blood vessels that feed into the upper glands," he explains. "Also, once you get the lower glands working better, the lids appose each other better; as a result, the pumping mechanism that accompanies blinking is more effective in the upper glands. Younger patients need fewer treatments.Third, some of the heat is transferred from the side treatment and the lower lids, so you get the warm compress effect on the upper gland indirectly. We've found that the upper glands also open up, allowing us to express them.

Asked whether the results could be attributed largely to the medications, Dr. Toyos says he doubts it. "My initial studies were done without any medications, but patients reported improvement and I saw objective improvement," he notes.
"Also, many patients have come to me after using all of these medications without getting relief. Finally, some of our patients have not used the drops due to cost or allergy, and they still show positive results. But the medications do help to prolong the time between needed retreatments."

Dr. Toyos notes that it usually takes a minimum of four and an average of 5-6 treatments no longer than 5 weeks apart from each other to get the secretions thin and working correctly. "After the gland is normalized we do maintenance treatments every six months to a year," he says. "Younger patients need fewer treatments."

Other surgeons are getting positive results as well. David R. Hardten, MD, director of refractive surgery for Minnesota Eye Consultants and Regions Hospital, and adjunct associate professor of ophthalmology at the University of Minnesota, is one of several surgeons around the country who has recently begun using the IPL treatment. "We began offering IPL four months ago," he says. "The treated patients have improved both subjectively and objectively. In our hands, it appears to be an excellent treatment for the patient that wants an alternative to the typical medication regimens we've used for years."